The set up is pretty simple. Remove front cover to unwrap the filter. Check the bulbs fir any damage. Secure the cover back on prior to plugging it in. Read all the warnings. The warning are very concerning for anyone with respiratory challenges. The remote is the only way to turn off the anionizer. We have ours running in our den, which is the only room left that is carpeted. Between the carpet, dust, and the pets, we are hoping this helps with my husbands allergies.